A novel onco-miR-365 induces cutaneous squamous cell carcinoma
نویسندگان
چکیده
منابع مشابه
A novel onco-miR-365 induces cutaneous squamous cell carcinoma
The expression levels of miR-365 vary in different malignancies. Herein, we found that miR-365 was overexpressed in both cells and clinical specimens of cutaneous squamous cell carcinoma (SCC). We demonstrated that the HaCaT(pre-miR-365-2) cell line, which overexpressed miR-365, could induce subcutaneous tumors in vivo. Antagomir-365, an anti-miR-365 oligonucleotide, inhibited cutaneous tumor f...
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Pro-apoptotic BCL2 associated X (BAX) is traditionally thought to be regulated by anti-apoptotic BCL-2 family members, like BCL2-like 1 (BCL-XL), at the protein level. However, the posttranscriptional regulation of BAX is under explored. In this study, we identified BAX as the novel downstream target of miR-365, which is supported by gain- and loss-of-function studies of onco-miR-365. Loss of B...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 2013
ISSN: 1460-2180,0143-3334
DOI: 10.1093/carcin/bgt097